MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer.

ABSTRACT: Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients' gene expression data, that MAGI1 is highly expressed and acts as tumor suppressor in estrogen receptor (ER)⁺/HER2^- but not in HER2⁺ or triple negative breast cancer (TNBC). Within the ER⁺/HER2^- subset, high MAGI1 expression associates with ESR1 and luminal genes GATA3 and FOXA1 expression and better prognosis, while low MAGI1 levels correlates with higher histological grade, more aggressive phenotype and worse p

SUBMITTER: Alday-Parejo B 

PROVIDER: S-EPMC7016640 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature