Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools.

ABSTRACT: Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within the population genetics community frequently overlook the importance of these criteria when associating observed phenotypic variation with evolutionary explanations. A functional investigation of population-specific variation using cutting-edge genome editing tools has the potential to empower the population genetics community by holding "just-so" evolutionary explanations accountable. Here, we detail currently available precision genome editing tools and methods, with a particular emphasis on base editing, that can be applied to functiona

SUBMITTER: Fox K 

PROVIDER: S-EPMC7016644 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature