Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype.

ABSTRACT: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Despite the progress of new treatments, the risk of recurrence, morbidity, and death remains significant and the long-term adverse effects in survivors are substantial. The fraction of cancer stem-like cells (CSCs) because of their self-renewal ability and multi-lineage differentiation potential is critical for tumor initiation, growth, and resistance to therapies. For the development of new CSC-targeted therapies, further in-depth studies are needed using enriched and stable MB-CSCs populations. This work, aimed at identifying the amount of CSCs in three available human cell lines (DAOY, D341, and D283), describes different approaches based on the expression of stemness markers. First, we explored potential differenc

SUBMITTER: Casciati A 

PROVIDER: S-EPMC7016648 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature