Is There an Interplay between Immune Checkpoint Inhibitors, Thromboprophylactic Treatments and Thromboembolic Events? Mechanisms and Impact in Non-Small Cell Lung Cancer Patients.

ABSTRACT: PD-1 pathway blockade has been shown to promote proatherogenic T-cell responses and destabilization of atherosclerotic plaques. Moreover, preclinical evidence suggests a potential synergy of antiplatelet drugs with immune checkpoint inhibitors (ICIs). We conducted an analysis within a prospective observational protocol (APOLLO study) to investigate the rates, predictors, and prognostic significance of thromboembolic events (TE) and thromboprophylaxis in patients with advanced NSCLC treated with ICIs. Among 217 patients treated between April 2014 and September 2018, 13.8% developed TE events. Current smoking status (HR 3.61 (95% CI 1.52-8.60), p = 0.004) and high (>50%) PD-L1 (HR 2.55 (95% CI 1.05-6.19), p = 0.038) resulted in being independent TE predictors. An increased risk

SUBMITTER: Nichetti F 

PROVIDER: S-EPMC7016680 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature