Priority Strategy of Intracellular Ca2+ Homeostasis in Skeletal Muscle Fibers During the Multiple Stresses of Hibernation.

ABSTRACT: : Intracellular calcium (Ca2+) homeostasis plays a vital role in the preservation of skeletal muscle. In view of the well-maintained skeletal muscle found in Daurian ground squirrels (Spermophilus dauricus) during hibernation, we hypothesized that hibernators possess unique strategies of intracellular Ca2+ homeostasis. Here, cytoplasmic, sarcoplasmic reticulum (SR), and mitochondrial Ca2+ levels, as well as the potential Ca2+ regulatory mechanisms, were investigated in skeletal muscle fibers of Daurian ground squirrels at different stages of hibernation. The results showed that cytoplasmic Ca2+ levels increased in the skeletal muscle fibers during late torpor (LT) and inter-bout arousal (IBA), and partially recovered when the animals re-entered torpor (early torpor, ET). Furthermore, compa

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7016685 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature