Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage.

ABSTRACT: Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an evolutionary divergence. Mouse TRPA1 was implicated in noxious cold detection but was later also identified as one of the prime noxious heat sensors. Moreover, human TRPA1, originally considered to be temperature-insensitive, turned out to act as an intrinsic bidirectional thermosensor that is capable of sensing both cold and heat. Using electrophysiology and modeling, we compare the properties of human and mouse TRPA1, and we demonstrate that both orthologues are activated by heat, and their kinetically distinct components of voltage-dependent gatin

SUBMITTER: Sinica V 

PROVIDER: S-EPMC7016720 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature