CD276-Positive Circulating Endothelial Cells Do Not Predict Response to Systemic Therapy in Advanced Colorectal Cancer.

ABSTRACT: CD276 can discriminate between tumor derived and normal CECs (circulating endothelial cells). We evaluated whether CD276⁺CEC is a clinically relevant biomarker to predict response to palliative systemic therapy in patients with metastatic colorectal cancer (mCRC). Samples were prospectively collected from patients with mCRC enrolled in the ORCHESTRA trial (NCT01792934). At baseline and after three cycles of 5-fluorouracil/leucovorin and oxaliplatin ± bevacizumab, CECs were measured by flowcytometry (CD34⁺CD45^negCD146⁺DNA⁺; and CD276⁺). A clinically relevant cut-off value of (CD276⁺)CECs was determined as 100% sensitivity (and 80% specificity in 95% confidence interval) identifying patients with progressive disease

SUBMITTER: Gootjes EC 

PROVIDER: S-EPMC7016770 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature