Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice.

ABSTRACT: Tau dysfunction is common in several neurodegenerative diseases including Alzheimer's disease (AD) and frontotemporal dementia (FTD). Affective symptoms have often been associated with aberrant tau pathology and are commonly comorbid in patients with tauopathies, indicating a connection between tau functioning and mechanisms of depression. The current study investigated depression-like behavior in Mapt-/- mice, which contain a targeted deletion of the gene coding for tau. We show that 6-month Mapt-/- mice are resistant to depressive behaviors, as evidenced by decreased immobility time in the forced swim and tail suspension tests, as well as increased escape behavior in a learned helplessness task. Since depression has also been linked to deficient adult neurogenesis, we measured neurogenes

SUBMITTER: Criado-Marrero M 

PROVIDER: S-EPMC7016791 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature