Role of the interferons in CD64 and CD169 expressions in whole blood: Relevance in the balance between viral- or bacterial-oriented immune responses.

ABSTRACT:

Introduction

CD64 expression increases on neutrophils during bacterial infections. Recently an increase in CD169 expression has been discovered on monocytes during viral infections. Generally, interferons α (IFNsα) and IFNsγ are key drivers of the infectious host immune response. The purpose of this study was to explore if a link exists between these IFNs and both biomarkers.

Methods

Whole blood samples from healthy volunteers were stimulated with either IFNs, interleukins, or infectious extracts, to mimic an infectious state. Expressions of CD64 and CD169 were assessed in these samples by multiple flow cytometry methods, over precise kinetics.

Results

The expression of CD64 was statistically higher in samples stimulated with IFNγ, and CD169 in those stimulated with I

SUBMITTER: Bourgoin P 

PROVIDER: S-EPMC7016842 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature