Toxicological Risks of Renqingchangjue in Rats Evaluated by 1H NMR-Based Serum and Urine Metabolomics Analysis.

ABSTRACT: Renqingchangjue (RQCJ), a kind of Traditional Tibetan Medicine, has been widely utilized to treat various gastroenteritis diseases. However, the biosafety and toxicity of RQCJ was still indefinite because of toxic components in RQCJ, which included a variety of heavy metals. Thus, this study was aimed to evaluate the toxicity and expound the toxicological mechanism of RQCJ. In this study, rats were intragastrically administered with different doses of RQCJ for 15 days, and then, the restorative observation period lasted for 15 days. Liver and kidney tissues were collected for histopathological examination, and simultaneously serum and urine samples were collected for 1H nuclear magnetic resonance (1H NMR) spectroscopy analysis and biochemical analysis combined with inductively coupled plas

SUBMITTER: Wang X 

PROVIDER: S-EPMC7016918 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature