Ontology highlight
ABSTRACT:
SUBMITTER: Brachet-Botineau M
PROVIDER: S-EPMC7016966 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cancers 20200118 1
Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated in hematopoietic cancers. STAT3 and STAT5 are common targets for different tyrosine kinase oncogenes (TKOs). In addition, STAT3 and STAT5 proteins were shown to contain activating mutations in some rare but aggressive leukemias/lymphomas. Both proteins also contribute to drug resistance in hematopoietic malignancies and ...[more]