Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer.

ABSTRACT: Previously, based on a DNA microarray experiment, we identified a 96-gene prognostic signature associated with the shorter survival of ovarian cancer patients. We hypothesized that some differentially expressed protein-coding genes from this signature could potentially serve as prognostic markers. The present study was aimed to validate two proteins, namely fibronectin (FN1) and periostin (POSTN), in the independent set of ovarian cancer samples. Both proteins are mainly known as extracellular matrix proteins with many important functions in physiology. However, there are also indications that they are implicated in cancer, including ovarian cancer. The expression of these proteins was immunohistochemically analyzed in 108 surgical samples of advanced ovarian cancer (majority: high-grade s

SUBMITTER: Kujawa KA 

PROVIDER: S-EPMC7016975 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature