Brain Invasion along Perivascular Spaces by Glioma Cells: Relationship with Blood-Brain Barrier.

ABSTRACT: The question whether perivascular glioma cells invading the brain far from the tumor bulk may disrupt the blood-brain barrier (BBB) represents a crucial issue because under this condition tumor cells would be no more protected from the reach of chemotherapeutic drugs. A recent in vivo study that used human xenolines, demonstrated that single glioma cells migrating away from the tumor bulk are sufficient to breach the BBB. Here, we used brain xenografts of patient-derived glioma stem-like cells (GSCs) to show by immunostaining that in spite of massive perivascular invasion, BBB integrity was preserved in the majority of vessels located outside the tumor bulk. Interestingly, the tumor cells that invaded the brain for the longest distances traveled along vessels with retained BBB integrity. I

SUBMITTER: Pacioni S 

PROVIDER: S-EPMC7017006 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature