Pervasive Strong Selection at the Level of Codon Usage Bias in Drosophila melanogaster.

ABSTRACT: Codon usage bias (CUB), where certain codons are used more frequently than expected by chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant paradigm is that the proportion of preferred codons is set by weak selection. While experimental changes in codon usage have at times shown large phenotypic effects in contrast to this paradigm, genome-wide population genetic estimates have supported the weak selection model. Here we use deep genomic population sequencing of two Drosophila melanogaster populations to measure selection on synonymous sites in a way that allowed us to estimate the prevalence of both weak and strong purifying selection. We find that selection in favor of preferred codons ranges from weak (|N_es| ∼ 1) to strong (|N

SUBMITTER: Machado HE 

PROVIDER: S-EPMC7017021 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature