Protection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13.

ABSTRACT: XY C57BL/6J (B6) mice harboring a Mus musculus domesticus-type Y chromosome (Y ^POS ), known as B6.Y ^POS mice, commonly undergo gonadal sex reversal and develop as phenotypic females. In a minority of cases, B6.Y ^POS males are identified and a proportion of these are fertile. This phenotypic variability on a congenic B6 background has puzzled geneticists for decades. Recently, a B6.Y ^POS colony was shown to carry a non-B6-derived region of chromosome 11 that protected against B6.Y ^POS sex reversal. Here. we show that a B6.Y ^POS colony bred and archived at the MRC Harwell Institute lacks the chromosome 11 modifier but instead harbors an ∼37 Mb region containing non-B6-derived se

SUBMITTER: Livermore C 

PROVIDER: S-EPMC7017026 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature