Cell Electropermeabilisation Enhancement by Non-Thermal-Plasma-Treated PBS.

ABSTRACT: The effectiveness of electrochemotherapy (ECT) in local eradication of tumours in human and veterinary medicine has been proven. ECT consists of increasing the uptake of cytotoxic drugs by means of pulsed electric fields (PEFs) that transiently permeabilise the cell membrane. Still, this tumour treatment includes some drawbacks that are linked to the characteristics of the intense electric pulses (EPs) used. Meanwhile, the emerging field of cancer therapies that are based on the application of non-thermal plasmas (NTP) has recently garnered interest because of their potentialities as rich sources of reactive species. In this work, we investigated the potential capabilities of the combined application of indirect NTP treatment and microsecond PEFs (µsPEFs) to outperform in vitro cell electr

SUBMITTER: Chung TH 

PROVIDER: S-EPMC7017069 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature