Evaluation of the Abundance of DNA-Binding Transcription Factors in Prokaryotes.

ABSTRACT: The ability of bacteria and archaea to modulate metabolic process, defensive response, and pathogenic capabilities depend on their repertoire of genes and capacity to regulate the expression of them. Transcription factors (TFs) have fundamental roles in controlling these processes. TFs are proteins dedicated to favor and/or impede the activity of the RNA polymerase. In prokaryotes these proteins have been grouped into families that can be found in most of the different taxonomic divisions. In this work, the association between the expansion patterns of 111 protein regulatory families was systematically evaluated in 1351 non-redundant prokaryotic genomes. This analysis provides insights into the functional and evolutionary constraints imposed on different classes of regulatory factors in ba

SUBMITTER: Sanchez I 

PROVIDER: S-EPMC7017128 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature