Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.

ABSTRACT: The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter- and intra-cellular communication, which regulates fundamental cell functions such as growth, survival, and differentiation. The MAPK pathway also integrates signals from complex intracellular networks in performing cellular functions. Despite the initial discovery of the core elements of the MAPK pathways nearly four decades ago, additional findings continue to make a thorough understanding of the molecular mechanisms involved in the regulation of this pathway challenging. Considerable effort has been focused on the regulation of RAF, especially after the discovery of drug resistance and paradoxical activation upon inhibitor binding to the kinase. RAF activity is regulated by phosphorylation and conformation-dependen

SUBMITTER: Degirmenci U 

PROVIDER: S-EPMC7017232 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature