An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization.

ABSTRACT: Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide. Neovascularization encompasses both angiogenesis, the sprouting of new capillaries from existing vessels, and arteriogenesis, the maturation of preexisting collateral arterioles into fully functional arteries. Both angiogenesis and arteriogenesis are highly multifactorial processes that require a multifactorial regulator to be stimulated simultaneously. MicroRNAs can regulate both angiogenesis and arteriogenesis due to their ability to modulate expression of many genes simultaneously. Recent studies have revealed that many microRNAs have variants with altered terminal sequences, known as isomiRs. Additionally, endogenous microRNAs have be

SUBMITTER: van der Kwast RVCT 

PROVIDER: S-EPMC7017316 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature