The Length and Distribution of Plasma Cell-Free DNA Fragments in Stroke Patients.

ABSTRACT: A number of studies have shown that plasma cell-free DNA is closely related to the risk of stroke, but the fragmentation status of plasma cell-free DNA and its clinical application value in ischemic stroke are still unclear. In this study, 48 patients with new ischemic stroke and 20 healthy subjects were enrolled. The second-generation high-throughput sequencing technique was used to study the plasma cell-free fragment length and regional distribution of the subjects. As noted in our results, the ratio of plasma cell-free DNA fragments in the disease group was significantly greater than that of the healthy group in the 300-400 bp range; conversely for fragments at the 75-250 bp range, the ratio of plasma cell-free DNA fragments in the patient group was apparently lower than that of the hea

SUBMITTER: Cui X 

PROVIDER: S-EPMC7017581 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature