Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.

ABSTRACT:

Introduction

The number of aging cancer patients has increased continuously and will do so further in the future. The immune system of elderly people experiences critical changes over the time. Therefore, tumor-induced changes in the immune system are believed to differ in young and elderly cancer patients as well.

Methods

The effect of aging on the immune system was measured in peripheral blood lymphocytes (PBL) of healthy volunteers (n = 48, 21-84 yrs.) divided into three different age groups. Seventy years was set as a cut-off for defining subjects as elderly. Results were compared to two groups of adult cancer patients, which donated PBL and tumor infiltrating lymphocytes (TIL): young cancer patients (40-69 yrs.; blood: n = 13; TIL: n = 17) and elder

SUBMITTER: Jeske SS 

PROVIDER: S-EPMC7017629 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature