Fluid resuscitation-related coagulation impairment in a porcine hemorrhagic shock model.

ABSTRACT:

Background

Fast and effective treatment of hemorrhagic shock is one of the most important preclinical trauma care tasks e.g., in combat casualties in avoiding severe end-organ damage or death. In scenarios without immediate availability of blood products, alternate regimens of fluid resuscitation represent the only possibility of maintaining sufficient circulation and regaining adequate end-organ oxygen supply. However, the fluid choice alone may affect the extent of the bleeding by interfering with coagulation pathways. This study investigates the impact of hydroxyethyl starch (HES), gelatine-polysuccinate (GP) and balanced electrolyte solution (BES) as commonly used agents for fluid resuscitation on coagulation using a porcine hemorrhagic shock model.

Methods

Following app

SUBMITTER: Ziebart A 

PROVIDER: S-EPMC7017792 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature