Prognostic analysis of very early onset pancreatic cancer: a population-based analysis.

ABSTRACT:

Background

We aimed to use competing risk model to assess whether very early onset pancreatic cancer (VEOPC ) (<45 years) had a worse prognosis than older pancreatic cancer (PC) patients, and to build a competing risk nomogram for predicting the risk of death of VEOPC.

Methods

We selected pancreatic adenocarcinoma (PDAC) patients as our cohort from the Surveillance, Epidemiology, and End Results (SEER) database. The impact of cancer specific death was estimated by competing risk analysis. Multivariate Fine-Gray regression for proportional hazards modeling of the subdistribution hazard (SH) model based nomogram was constructed, which was internally validated by discrimination and calibration with 1,000 bootstraps.

Results

Our cohort included 1,386 VEOPC patients and 53

SUBMITTER: Dai D 

PROVIDER: S-EPMC7017800 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature