Maternal serum metabolome and traffic-related air pollution exposure in pregnancy.

ABSTRACT:

Background

Maternal exposure to traffic-related air pollution during pregnancy has been shown to increase the risk of adverse birth outcomes and neurodevelopmental disorders. By utilizing high-resolution metabolomics (HRM), we investigated perturbations of the maternal serum metabolome in response to traffic-related air pollution to identify biological mechanisms.

Methods

We retrieved stored mid-pregnancy serum samples from 160 mothers who lived in the Central Valley of California known for high air particulate levels. We estimated prenatal traffic-related air pollution exposure (carbon monoxide, nitric oxides, and particulate matter <2.5 μm) during first-trimester using the California Line Source Dispersion Model, version 4 (CALINE4) based on residential addresses recorded

SUBMITTER: Yan Q 

PROVIDER: S-EPMC7017857 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature