A transition-metal-free & diazo-free styrene cyclopropanation.

ABSTRACT: An operationally simple and broadly applicable novel cyclopropanation of styrenes using gem-diiodomethyl carbonyl reagents has been developed. Visible-light triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity and functional group tolerance. To highlight the utility of our photocyclopropanation, we demonstrated the late-stage functionalization of biomolecule derivatives.

SUBMITTER: Herraiz AG 

PROVIDER: S-EPMC7017872 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature