Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.

ABSTRACT:

Background

Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well studied.

Objectives

To test the association between genetic variants and the clinical features of Parkinson's disease on a genomewide scale.

Methods

We accumulated individual data from 12 longitudinal cohorts in a total of 4093 patients with 22,307 observations for a median of 3.81 years. Genomewide associations were evaluated for 25 cross-sectional and longitudinal phenotypes. Specific variants of interest, including 90 recently identified disease-risk variants, were also investigate

SUBMITTER: Iwaki H 

PROVIDER: S-EPMC7017876 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature