The moderating effect of FKBP5 and 5-HTTLPR polymorphisms on the day-level association between drinking to cope motivation and negative affect.

ABSTRACT: Daily levels of drinking to cope (DTC) have been found to be related to negative outcomes such as increased negative affect, and these effects vary across person. We examined whether daily-level effects of DTC motivation were related to two genetic polymorphisms (rs1360780 in the FKBP5 gene and 5-HTTLPR in SLC6A4) thought to be associated with maladaptive drinking and stress-reactivity. We also examined whether these associations changed during the transition from college to post-college life. Participants (N = 839, 55% women) completed an Internet-based 30-day daily diary during college and again five years later in which they reported their previous night's drinking and drinking motivation, and their current day's negative affect. Saliva was collected at wave 1 to provide DNA for genotyp

SUBMITTER: Covault J 

PROVIDER: S-EPMC7017904 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature