Concise asymmetric synthesis of (-)-bilobalide.

ABSTRACT: The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood^1-4. Antagonism of γ-aminobutyric acid A receptors (GABA_ARs) by bilobalide has been linked to the rescue of cognitive deficits in mouse models of Down syndrome⁵. A lack of convulsant activity coupled with neuroprotective effects have led some to postulate an alternative, unidentified target⁴; however, steric congestion and the instability of bilobalide^1,2,6 have prevented pull-down of biological targets other than the GABA_ΑRs. A concise and flexible synthesis of bilobalide would facilitate the development of probes for the identification of potential new targets, analogues with di

SUBMITTER: Baker MA 

PROVIDER: S-EPMC7017908 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature