Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury.

ABSTRACT:

Objectives

Determine the intra-tidal regional gas and blood volume distributions at different levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration and blood volume matching is reduced during inspiration in the setting of minimal tidal recruitment/derecruitment and that this mismatching is an important determinant of hypoxemia.

Design

Preclinical study.

Setting

Research laboratory.

Subjects

Seven anesthetized pigs 28.7 kg (SD, 2.1 kg).

Interventions

All animals received a saline-lavage surfactant depletion lung injury model. Positive end-expiratory pressure was varied between 0 and 20 cm H2O to induce different levels of atelectasis.

Measurements and main results

Dynamic dual-energy CT images of a juxtadiap

SUBMITTER: Cronin JN 

PROVIDER: S-EPMC7017942 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature