Flow-Controlled Ventilation Attenuates Lung Injury in a Porcine Model of Acute Respiratory Distress Syndrome: A Preclinical Randomized Controlled Study.

ABSTRACT:

Objectives

Lung-protective ventilation for acute respiratory distress syndrome aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. "Flow-controlled ventilation", providing a constant expiratory flow, has been suggested as a new lung-protective ventilation strategy. The aim of this study was to test whether flow-controlled ventilation attenuates lung injury in an animal model of acute respiratory distress syndrome.

Design

Preclinical, randomized controlled animal study.

Setting

Animal research facility.

Subjects

Nineteen German landrace hybrid pigs.

Intervention

Flow-controlled ventilation (intervention group) or volume-controlled ventilation (control group) with identical t

SUBMITTER: Schmidt J 

PROVIDER: S-EPMC7017946 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature