Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock.

ABSTRACT:

Background

Resuscitation from hemorrhagic shock (HS) by blood transfusion restores oxygen (O2) delivery and provides hemodynamic stability. Current regulations allow red blood cells (RBCs) to be stored and used for up to 42 days. During storage, RBCs undergo many structural and functional changes. These storage lesions have been associated with adverse events and increased mortality after transfusion, increasing the need for improved RBC storage protocols. This study evaluates the efficacy of anaerobically stored RBCs to resuscitate rats from severe HS compared with conventionally stored RBCs.

Methods and results

Rat RBCs were stored under anaerobic, anaerobic/hypercapnic, or conventional conditions for a period of 3 weeks. Hemorrhage was induced by controlled bleeding, shoc

SUBMITTER: Williams AT 

PROVIDER: S-EPMC7017949 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature