Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection.

ABSTRACT: BACKGROUND:Ascaris lumbricoides is one of the three major soil-transmitted gastrointestinal helminths (STHs) that infect more than 440 million people in the world, ranking this neglected tropical disease among the most common afflictions of people living in poverty. Children infected with this roundworm suffer from malnutrition, growth stunting as well as cognitive and intellectual deficits. An effective vaccine is urgently needed to complement anthelmintic deworming as a better approach to control helminth infections. As37 is an immunodominant antigen of Ascaris suum, a pig roundworm closely related to the human A. lumbricoides parasite, recognized by protective immune sera from A. suum infected mice. In this study, the immunogenicity and vaccine efficacy of recombinant As37 were evaluate

SUBMITTER: Versteeg L 

PROVIDER: S-EPMC7017989 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature