A generative growth model for thalamocortical axonal branching in primary visual cortex.

ABSTRACT: Axonal morphology displays large variability and complexity, yet the canonical regularities of the cortex suggest that such wiring is based on the repeated initiation of a small set of genetically encoded rules. Extracting underlying developmental principles can hence shed light on what genetically encoded instructions must be available during cortical development. Within a generative model, we investigate growth rules for axonal branching patterns in cat area 17, originating from the lateral geniculate nucleus of the thalamus. This target area of synaptic connections is characterized by extensive ramifications and a high bouton density, characteristics thought to preserve the spatial resolution of receptive fields and to enable connections for the ocular dominance columns. We compare indi

SUBMITTER: Kassraian-Fard P 

PROVIDER: S-EPMC7018004 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature