Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin.

ABSTRACT:

Background and aims

The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has been proposed as a possible treatment of acute alcohol withdrawal. The aim of the present study was to explore whether actigraphy could be used as a tool to register symptoms during alcohol detoxification, whether oxytocin affected actigraphy variables related to motor activity and sleep compared to placebo during detoxification, and whether actigraphy-recorded motor function during detoxification was different from that in healthy controls.

Methods

This study was a part of a randomized, double blind, placebo-controlled trial in which 40 patients with alcohol

SUBMITTER: Melby K 

PROVIDER: S-EPMC7018062 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature