SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy.

ABSTRACT: Drug combinations are becoming a standard treatment of many complex diseases due to their capability to overcome resistance to monotherapy. In the current preclinical drug combination screening, the top combinations for further study are often selected based on synergy alone, without considering the combination efficacy and toxicity effects, even though these are critical determinants for the clinical success of a therapy. To promote the prioritization of drug combinations based on integrated analysis of synergy, efficacy and toxicity profiles, we implemented a web-based open-source tool, SynToxProfiler (Synergy-Toxicity-Profiler). When applied to 20 anti-cancer drug combinations tested both in healthy control and T-cell prolymphocytic leukemia (T-PLL) patient cells, as well as to 77 anti-

SUBMITTER: Ianevski A 

PROVIDER: S-EPMC7018095 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature