Multiple protein-DNA interfaces unravelled by evolutionary information, physico-chemical and geometrical properties.

ABSTRACT: Interactions between proteins and nucleic acids are at the heart of many essential biological processes. Despite increasing structural information about how these interactions may take place, our understanding of the usage made of protein surfaces by nucleic acids is still very limited. This is in part due to the inherent complexity associated to protein surface deformability and evolution. In this work, we present a method that contributes to decipher such complexity by predicting protein-DNA interfaces and characterizing their properties. It relies on three biologically and physically meaningful descriptors, namely evolutionary conservation, physico-chemical properties and surface geometry. We carefully assessed its performance on several hundreds of protein structures and compared it to

SUBMITTER: Corsi F 

PROVIDER: S-EPMC7018136 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature