Intracranial pressure modulates aqueous humour dynamics of the eye.

ABSTRACT:

Key points

An elevation in intracranial pressure (ICP) lowers conventional outflow facility (increases aqueous outflow resistance) of rat eyes. The reduction in outflow facility correlates with an increase in intraocular pressure (IOP). The effect of ICP elevation on outflow facility and IOP is blocked by TTX. The results indicate that aqueous humour dynamics is modulated by ICP-driven neural feedback from the brain. This feedback mechanism may act to stabilize translaminar pressure across the optic nerve head and may provide a new avenue for glaucoma therapy.

Abstract

While intraocular pressure (IOP) is a well-known risk factor for glaucoma, intracranial pressure (ICP) is attracting heightened interest because of its influence on optic nerve head biomechanics. Studies have

SUBMITTER: Ficarrotta KR 

PROVIDER: S-EPMC7018442 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature