Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees.

ABSTRACT: Cell heterogeneity may be caused by stochastic or deterministic effects. The inheritance of regulators through cell division is a key deterministic force, but identifying inheritance effects in a systematic manner has been challenging. Here, we measure and analyze cell cycles in deep lineage trees of human cancer cells and mouse embryonic stem cells and develop a statistical framework to infer underlying rules of inheritance. The observed long-range intra-generational correlations in cell-cycle duration, up to second cousins, seem paradoxical because ancestral correlations decay rapidly. However, this correlation pattern is naturally explained by the inheritance of both cell size and cell-cycle speed over several generations, provided that cell growth and division are coupled through a min

SUBMITTER: Kuchen EE 

PROVIDER: S-EPMC7018508 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature