Risk stratification biomarkers for Staphylococcus aureus bacteraemia.

ABSTRACT:

Objectives

To identify risk stratification biomarkers to enrich for the subset of Staphylococcus aureus bacteraemia patients who develop deep-seated tissue infections with high morbidity and mortality to guide clinical trial enrolment and clinical management.

Methods

We evaluated the prognostic value of eight biomarkers for persistent bacteraemia, mortality and endovascular infection foci in a validation cohort of 160 patients with S. aureus bacteraemia enrolled consecutively over 3 years.

Results

High levels of IL-17A, IL-10 or soluble E-selectin at bacteraemia diagnosis correlated with the duration of positive blood cultures. When thresholds defined in an independent cohort were applied, these biomarkers were robust predictors of persistent bacteraemia

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7018520 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature