Ontology highlight
ABSTRACT:
SUBMITTER: Qin S
PROVIDER: S-EPMC7018538 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Qin Sisi S Eugene Andy R AR Liu Duan D Zhang Lingxin L Neavin Drew D Biernacka Joanna M JM Yu Jia J Weinshilboum Richard M RM Wang Liewei L
Clinical pharmacology and therapeutics 20191130 3
We previously reported that testis-specific Y-encoded-like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles for TSPYLs in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors (SSRIs) in patients with major depressive disorder (MDD). The widely prescribed SSRIs, citalopram, and escitalopram are metabolized mainly by CYP2C19. The TSPYL1 rs3828743 single nucleotide polymorphism (SNP), which decreases i ...[more]