Ontology highlight
ABSTRACT:
SUBMITTER: Dwivedi SKD
PROVIDER: S-EPMC7018556 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20191223 2
Using a systems biology approach to prioritize potential points of intervention in ovarian cancer, we identified the lysine rich coiled-coil 1 (KRCC1), as a potential target. High-grade serous ovarian cancer patient tumors and cells express significantly higher levels of KRCC1 which correlates with poor overall survival and chemoresistance. We demonstrate that KRCC1 is predominantly present in the chromatin-bound nuclear fraction, interacts with HDAC1, HDAC2, and with the serine-threonine phosph ...[more]