Presence and structure-activity relationship of intrinsically disordered regions across mucins.

ABSTRACT: Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion. The large size and extensive glycosylation present challenges to study the mucin structure using traditional methods, including crystallography. We offer the hypothesis that the functional versatility of mucins may be attributed to the presence of intrinsically disordered regions (IDRs) that provide dynamism and flexibility and that the IDRs offer potential therapeutic targets. Herein, we examined the links between the mucin structure and function based on IDRs, posttranslational modifications (PTMs), and potential impact on their interactome. Using sequence-based bioinformati

SUBMITTER: Carmicheal J 

PROVIDER: S-EPMC7018569 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature