Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.

ABSTRACT: Allergic asthma with high plasma IgE levels is a significant risk factor of human abdominal aortic aneurysm (AAA). This study tests a direct role of IgE in angiotensin-II (Ang-II) perfusion- and peri-aortic CaCl₂ injury-induced AAA in mice. In both models, IgE-deficiency in Apoe^-/- Ige^-/- mice blunts AAA growth and reduces lesion accumulation of macrophages, CD4⁺ and CD8⁺ T cells, and lesion MHC class-II expression, CD31⁺ microvessel growth, and media smooth muscle cell loss, compared with those from Apoe^-/- control mice. Real time-PCR reveals significant reductions in expression of neutrophil chemoattractants MIP-2α and CXCL5 in AAA lesions or macrophages from Apoe^-/- Ige^-/- mice, along with

SUBMITTER: Li J 

PROVIDER: S-EPMC7018578 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature