Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure.

ABSTRACT: Most infants with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in nutrient malabsorption and requires oral pancreatic enzyme replacement. Newborn screening for CF has enabled earlier diagnosis, nutritional intervention and enzyme replacement for these infants, allowing most infants with CF to achieve their weight goals by 12 months of age¹. Nevertheless, most infants with CF continue to have poor linear growth during their first year of life¹. Although this early linear growth failure is associated with worse long-term respiratory function and survival^2,3, the determinants of body length in infants with CF have not been defined. Several characteristics of the CF gastrointestinal (GI) tract, including inflammation, maldigestion an

SUBMITTER: Hayden HS 

PROVIDER: S-EPMC7018602 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature