Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity.

ABSTRACT: Combination antiretroviral therapy (ART) is highly effective in controlling human immunodeficiency virus (HIV)-1 but requires lifelong medication due to the existence of a latent viral reservoir^1,2. Potent broadly neutralizing antibodies (bNAbs) represent a potential alternative or adjuvant to ART. In addition to suppressing viremia, bNAbs may have T cell immunomodulatory effects as seen for other forms of immunotherapy³. However, this has not been established in individuals who are infected with HIV-1. Here, we document increased HIV-1 Gag-specific CD8⁺ T cell responses in the peripheral blood of all nine study participants who were infected with HIV-1 with suppressed blood viremia, while receiving bNAb therapy during ART interruption⁴. Increase

SUBMITTER: Niessl J 

PROVIDER: S-EPMC7018622 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature