Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy.

ABSTRACT: The receptor binding protein of parainfluenza virus, hemagglutinin-neuraminidase (HN), is responsible for actively triggering the viral fusion protein (F) to undergo a conformational change leading to insertion into the target cell and fusion of the virus with the target cell membrane. For proper viral entry to occur, this process must occur when HN is engaged with host cell receptors at the cell surface. It is possible to interfere with this process through premature activation of the F protein, distant from the target cell receptor. Conformational changes in the F protein and adoption of the postfusion form of the protein prior to receptor engagement of HN at the host cell membrane inactivate the virus. We previously identified small molecules that interact with HN and induce it to activ

SUBMITTER: Marcink TC 

PROVIDER: S-EPMC7018645 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature