Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells.

ABSTRACT: Periodontal diseases can lead to chronic inflammation affecting the integrity of the tooth supporting tissues. Recently, a striking association has been made between periodontal diseases and primary cancers in the absence of a mechanistic understanding. Here we address the effect of periodontal inflammation (PI) on tumor progression, metastasis, and possible underlining mechanisms. We show that an experimental model of PI in mice can promote lymph node (LN) micrometastasis, as well as head and neck metastasis of 4T1 breast cancer cells, both in early and late stages of cancer progression. The cervical LNs had a greater tumor burden and infiltration of MDSC and M2 macrophages compared with LNs at other sites. Pyroptosis and the resultant IL-1β production were detected in patients with PI, m

SUBMITTER: Cheng R 

PROVIDER: S-EPMC7018659 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature