Effect of single dose N-acetylcysteine administration on resting state functional connectivity in schizophrenia.

ABSTRACT:

Rationale

There is interest in employing N-acetylcysteine (NAC) in the treatment of schizophrenia, but investigations of the functional signatures of its pharmacological action are scarce.

Objectives

The aim of this study was to identify the changes in resting-state functional connectivity (rs-FC) that occur following administration of a single dose of NAC in patients with schizophrenia. A secondary aim was to examine whether differences in rs-FC between conditions were mediated by glutamate metabolites in the anterior cingulate cortex (ACC).

Methods

In a double-blind, placebo-controlled crossover design, 20 patients with schizophrenia had two MRI scans administered 7 days apart, following oral administration of either 2400 mg NAC or placebo. Resting state functional

SUBMITTER: McQueen G 

PROVIDER: S-EPMC7018675 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature