Radiogenomics predicts the expression of microRNA-1246 in the serum of esophageal cancer patients.

ABSTRACT: Radiogenomics is a new field that provides clinically useful prognostic predictions by linking molecular characteristics such as the genetic aberrations of malignant tumors with medical images. The abnormal expression of serum microRNA-1246 (miR-1246) has been reported as a prognostic factor of esophageal squamous cell carcinoma (ESCC). To evaluate the power of the miR-1246 level predicted with radiogenomics techniques as a predictor of the prognosis of ESCC patients. The real miR-1246 expression (miR-1246_real) was measured in 92 ESCC patients. Forty-five image features (IFs) were extracted from tumor regions on contrast-enhanced computed tomography. A prediction model for miR-1246_real was constructed using linear regression with selected features identified in a corr

SUBMITTER: Hoshino I 

PROVIDER: S-EPMC7018689 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature