Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.

ABSTRACT: Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment leads to deleterious effects on health and healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. Non-biased RNA sequencing analysis using liver and kidney showed marked activation of gene regulatory pathways associated with the immune system and immune disease in both organs. In accordance, we observed enhanced steatohepatitis with infiltration of inflammatory cells. The investigation of senescence-associated immune cell subsets from the

SUBMITTER: Inokawa H 

PROVIDER: S-EPMC7018741 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature